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Jan 26, 2010
Andrew

Accomplia Diet Pill

A diet pill known as Accomplia (Rimonabant) is causing a buzz among dieters in all parts of the world. Originally developed to help people stop smoking, Accomplia also appears to suppress appetite by blocking hunger signals to the brain.

Accomplia targets the endocannabinoid system, which controls appetite and energy expenditure (as well as the urge to smoke). People who tend to overeat often have an over-stimulated endocannabinoid system. Accomplia blocks some receptors in the endocannabinoid system, giving it better balance, which in turn curbs appetite and the urge to overeat.

The French company Sanofi-Synthelabo is the creator of Accomplia, which it intends to market in the United States by as early as 2006 and possibly sooner in Europe. The drug has undergone thorough testing, with the first animal study conducted by the National Institute of Health in in 2001. In that study, genetically altered mice that lacked cannabinoid receptors were found to eat less than mice with an intact endocannabinoid system. The normal mice were then given Accomplia, and their food intake significantly decreased as well.

Human testing of Accomplia began in 2002. In one study, more than 1500 people participated in a trial in which they received either 5 mg per day of Accomplia, 20 mg per day of Accomplia or a placebo.

All of the participants began the study with a body mass index that classified them as obese, as well as high levels of blood fat, high blood pressure or both. Though approximately one third of participants dropped out of the study due to Accomplia side effects, the results support the claim that Accomplia is an effective weight loss medication.

After a year, more than 67 percent of those given a 20 mg dose of Accomplia had lost at least 5% of their original body weight, with 39% losing 10% of that weight or more. Those taking 5 mg doses of Accomplia lost more weight than those taking a placebo, but less weight than those taking 20 mg of the drug.

Another study reported by the American Heart Association included more than 3000 participants. The study showed that people who took Accomplia not only lost weight but showed lower levels of cholesterol, blood sugar and blood pressure, indicating that Accomplia may have the potential to replace other medications used to treat high blood pressure, high cholesterol and diabetes.

Time will tell whether the results of studies conducted on Accomplia are significant. Diet and exercise will likely always play a part in the battle against obesity, and it is possible that the 5-10% weight loss achieved in a year’s time by people using Accomplia can occur without the use of any medication, which always has the risk of side effects.

Accomplia side effects include gastrointestinal discomfort and dizziness. Mood disorders and headaches may be side effects as well. In general, Accomplia side effects seem to subside once adjustment to the drug is made.

Side effects also appear to be fewer and less severe than those of many other weight loss medications on the market. Accomplia, then, shows promise due to its relatively low incidence of side effects, as well as its positive effects on weight loss and its apparent ability to maintain healthy blood pressure, blood sugar and cholesterol levels.

Jan 26, 2010
Andrew

Adipex diet pills

Adipex diet pills, available as blue and clear capsules containing 30 mg of phentermine HCl, are one of the first drugs to be approved for obesity back in the 1950’s. This weight loss drug belongs to the class of noradrenergic stimulants that control hunger and are labeled as anorexiants.

How does Adipex work?

Adipex diet pills are said to mimic the action of sympathetic nervous system. This property has been found to be useful in the management of obesity. However, this appetite suppressing action of these drugs in treating obesity may not be the only explanation for their action. Other central nervous system actions, or metabolic effects, may be involved.

Adipex may be prescibed by a physician if a patient has failed to make progress on a conventional diet and exercise program over a period of 6 months. What’s “failure”, you ask? It’s usually described as the inability to lose about 1 lbs. per week of weight.

Therapy begins with 30 mg of the Adipex diet pill taken two hours before breakfast. This dosage is effective for suppression of appetite for a period of 12-14 hours. This effectively covers the period of the day in which food intake is most likely to occur. It’s a good idea to take Adipex in the morning, because taking it later in the day can lead to possible sleep disturbances. It’s stimulatory effect will go mostly unnoticed during the day and therefore, late evening administration of the drug is avoided.

The FDA recommends therapy for a duration of no longer than three months with Adipex diet pills. Natural mechanisms of the body to maintain a baseline environment cause an adaptation to the stimulatory actions of the drug. This leads to a tolerance and a gradual ineffectiveness of the drug as an appetite suppressant. Additionally, the absence of data relating to safety and efficacy of the drug after three months of therapy also is a factor for the short duration of prescription.

After therapy with Adipex diet pills for 3 months, it is unlikely that further increase in dose would bring about any continued weight loss and it is important not to increase the dose in anticipation of such an effect. Deviating from a previously tolerated dose is one of the major reasons for complications when using Adipex to support weight loss.

Adipex precautions:

The drug is not advisable for patients with co-existing diseases like advanced arteriosclerosis, coronary heart disease, moderate to severe hypertension, hyperthyroidism, glaucoma and known allergy to sympathomimetic drugs.

Adipex, when taken with antidepressants or with 14 days of them, may lead to very high blood-pressure. Adipex diet pills may elevate blood pressure and hence should be avoided even in mild hypertension.They may also decrease the efficacy of some antihypertensive drugs. The insulin requirements in diabetic patients who are on adipex will require modification as well.

Adipex diet pills should be taken by pregnant women only if it is decided that the benefits to the mother outweighs the risk to the fetus. In view of the potential for serious adverse reactions in nursing infants, mothers taking Adipex must not breast feed their child. The drug is not meant to be used in patients below the age of 16.

Adipex may impair the ability of the patient to engage in potentially hazardous activities such as operating machinery or driving a motor vehicle; the patient should therefore be cautioned accordingly.

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Hey it’s Andrew here. Thanks for visiting my site. I created this website to share my experience with diet pills. Mainly I'll talk about Phentermine pill, because in my opinion this is the Ultimate weight loss pill on the market nowadays. I bought and tried 4 different brands of weight loss pills, but I wasn’t impressed and didn't get the desired body weight with any of them until I came across a Phentermine pills. So read my story and few others really useful articles.

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